Glibenclamide


Glibenclamide (Sufonylurea)

Classifications: Sufonylurea- works only if pancreas has functioning beta cells.

Adjunct to diet and exercise to lower blood glucose levels in type 2 DM

Action:  Stimulate insulin release from the beta cells in the pancreas
–They improve binding to insulin receptors
-          Metabolized in liver and excreted in bile and urine
Safer for those with renal disease.

Adverse reactions:
–Hypoglycaemia
–GI distress : anorexia, nausea, vomiting, heartburn, diarrhoea
–Allergic skin reactions

 Contraindications: hypersensitivity, dka, diabetes complicated by fever, trauma, surgery ,renal or hepatic disease etc. Not for type 1 diabetics. Not for pregnancy.
Care considerations: Learn to recognize signs of hypoglycaemia and hyperglycaemia to effectively manage condition.
Drug-drug:
–Drugs that acidifies the urine
–Beta blockers

–Alcohol 

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