Clopidrogel

Clopidrogel hydrogen sulfate/ Iscover Plax Plavix                                 preg risk B

Indications: to reduce atherosclerotic events where there is MI, CVA or peripheral arterial disease.

  Action: ANTIPLATELET inhibits platelet aggregation, by inhibition of binding of ADP to its platelet receptor.Irreversible modification of platelet, LASTS FOR LIFETIME OF PLATELET-lasts 5days, indicated for those intolerant to aspirin.

Adverse:
CNS: headache, dizziness, fatigue, depression, pain
ENT: rhinitis, epistaxis
GI: haemorrhage, abdo pain, dyspepsia, gastritis, constipation, diarrhea, ulcers
GU: UTI
Haematologic: purpura
Musculoskeletal: arthralgia
Respiratory: bronchitis, coughing, dyspnea, upper respiratory tract infection
Skin: rash, pruritus
Flu-like syndrome

Contraindications:  hypersensitivity, those withy peptic ulcer, intracranial bleed, severe hepatic impairment, pregnancy, breastfeeding

Drug-drug: aspirin, nsaids, heparin, warfarin (all have bleeding actions)

Care considerations: caution if pregnant, reduces platelet count, bleeding,recent surgery, closed head injury.


Teaching:bleeding effects, inform all heath care providers(dentists etc), no meal requirements 

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