Glyceryl trinitrate

Glyceryl trinitrate (GTN)(Anginine, Nitrodur, Nitrolingual)

Class: antianginal agent                                                        
Actions: The nitrates relax and dilate veins, arteries and capillaries. Lowers systemic blood pressure. Cad causes stiffening, may not get response in coronary arteries. Blood flow through healthy vessels is increased. Main effect v BP. Relaxation of the vessels decreases afterload. Decrease workload of heart.

•Actions
–Act directly on smooth muscle to cause relaxation (vasodilation) and depress muscle tone

•Indications
–Prevention and treatment of attacks of angina pectoris (stable and unstable)
•Pharmacokinetics
–Very rapidly absorbed
–Metabolised in the liver
–Excreted in the urine



•Adverse Effects
–Related to vasodilatation and decreased blood flow
–CNS: Headache, dizziness and weakness
–GI: Nausea, vomiting
–CV: Hypotension
–Misc: Flushing, pallor increased perspiration


•Contraindications
–Allergy
–Severe anaemia
–Head trauma or cerebral haemorrhage
–Pregnancy and lactation

•Caution
–Hepatic or renal disease
–Hypotension, hypovolaemia, and conditions that limit cardiac output

Care
TAKE PULSE PRIOR TO ADMINISTRATION
Do not swallow
Tablets are s/l only
Light sensitive
Tingle under tongue- check expiry date
Patch – every 24 hours or as per order.
-          Use gloves(can be absorbed through fingers)
-          Write time on patch

-          Do not cut patch

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