Furosemide


Furosemide/ Frusid, Lasix

Classifications: diuretic. Used for acute pulmonary oedema

Adverse reactions:

 Toxicity- hearing (ototoxicity)

  CNS:vertigo , headache, dizziness, parasthesia, restlessness, weakness

    CV: volume depletion and dehydration, orthstatic hypotension, thrombophlebitis( with IV admin), fever with ischaemic complications

       Eye: blurred or yellowed vision

     GI: abdominal discomfort ant pain, diarrhoea, anorexia, nausea, vomiting, constipation, pancreatitis.

     GU: nocturia, polyuria, frequent urination, oliguria

    Haematologic: agranulocytosis, anaemia, aplastic anaemia, azotaemia, leucopenia, thrombocytopenia, thrombophilia(elderly) aplastic anaemia.

      Hepatic : hepatic dysfunction, cholestasis, jaundice  

     Metabolic: hypokalaemia-> arrhythmias, hypochloraemic alkalosis; asymptomatic hyperuricaemia

     Skin: dermatitis purpura, pruritus, photosensitivity, urticaria

Contraindications: hypersensitivity to this drug or sulfonamides, in those with anuria, hepatic coma or precoma, lactating women

Care considerations: onset of drug effect is one hour, and lasts 6- 8 hours. Caution in those with cirrhosis or are pregnant. Administer in the morning to prevent nocturia.

Alert: can lead to rapid water and electrolyte depletion. Cease if oliguria or azotaemia develops.

 Sorbitol component of drug may cause diarrhoea. Watch for signs of hypokalaemia(muscle weakness,cramps). May need a high potassium diet. Monitor bgls in those with diabetes mellitus.

Store tabs in light resistant container , regrigerate oral furosemide solution to ensure drug stability. Care with sodium intake- do not restrict.

Dose: 40 mg PO bid

Drug-drug: Aminoglycoside antibiotics, cisplatin; Amphotercin, corticosteroids, corticotropin, metolazone; anticonvulsants; antidiabetics; antihypetensives; cardiac glycosides, neuromuscular blockers; chloral hydrate; ethacrynic acid; Lithium, Neuromuscular blocking agents; NSAIDs; Theophyline; Salicylates; Sucralfate; take care in sun exposure

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