Bethanecol
Bethanachol chloride / Urocarb Preg risk B2
Classification: Cholinergic (parasympathomimetic)
Indications: acute postoperative (functional) and postpartum nonobstructive(functional) urine retention.
Action: Directly stimulates cholinergic receptors, mimicking the action of acetylcholine.
Adverse reactions:
CNS: headache, malaise, dizziness, drowsiness
eye: lacrimation, miosis
CV: bradycardia, profound hypotension with reflexive tachycardia
GI: abdominal cramps, diarrhoea, excessive salivation, nausea, belching, borborygmus
GU: urinary urgency
Hepatic: increased serum levels of amylase, lipase, bilirubin and AST
Respiratory: bronchoconstriction, increased bronchial secretions
Skin: flushing, sweating.
Drug-drug: anticholinergics, atropine, procainamide, quinidine.- possible reversed cholinergic effects. observe for lack of drug effect.
anticholinesterases, cholinergic agonists: possible additive effects or increased toxicity. avoid use together.
Contraindications: individuals with uncertain strength or integrity of bladder wall; when increased muscular activity of GI or urinary tract is harmful;in individual with mechanical obstructions of GI or urinary tract; those with hyperthyroidism, peptic ulceration, latent or active bronchial asthma, pronounced bradycardia or hypotension, vasomotor instability, cardiac or coronary artery disease, seizure disorder, Parkinson's disease, spastic GI disturbances, acute inflammatory lesions of GI tract, peritonitis.
Care considerations: use cautiously in pregnant women
give drug on empty stomach; otherwise, nausea and vomiting may occur.
monitor vital signs frequently esp respirations. Have atropine injection available and be prepared to give 0.5 mg SC or by slow IV push.
monitor urinary output and bladder retention
Maintain fluid intake and nutrition.
Teaching: take on empty stomach, drug is only effective within 30 - 90 mins after oral administration
Dose: available as 10 mg tabs
Classification: Cholinergic (parasympathomimetic)
Indications: acute postoperative (functional) and postpartum nonobstructive(functional) urine retention.
Action: Directly stimulates cholinergic receptors, mimicking the action of acetylcholine.
Adverse reactions:
CNS: headache, malaise, dizziness, drowsiness
eye: lacrimation, miosis
CV: bradycardia, profound hypotension with reflexive tachycardia
GI: abdominal cramps, diarrhoea, excessive salivation, nausea, belching, borborygmus
GU: urinary urgency
Hepatic: increased serum levels of amylase, lipase, bilirubin and AST
Respiratory: bronchoconstriction, increased bronchial secretions
Skin: flushing, sweating.
Drug-drug: anticholinergics, atropine, procainamide, quinidine.- possible reversed cholinergic effects. observe for lack of drug effect.
anticholinesterases, cholinergic agonists: possible additive effects or increased toxicity. avoid use together.
Contraindications: individuals with uncertain strength or integrity of bladder wall; when increased muscular activity of GI or urinary tract is harmful;in individual with mechanical obstructions of GI or urinary tract; those with hyperthyroidism, peptic ulceration, latent or active bronchial asthma, pronounced bradycardia or hypotension, vasomotor instability, cardiac or coronary artery disease, seizure disorder, Parkinson's disease, spastic GI disturbances, acute inflammatory lesions of GI tract, peritonitis.
Care considerations: use cautiously in pregnant women
give drug on empty stomach; otherwise, nausea and vomiting may occur.
monitor vital signs frequently esp respirations. Have atropine injection available and be prepared to give 0.5 mg SC or by slow IV push.
monitor urinary output and bladder retention
Maintain fluid intake and nutrition.
Teaching: take on empty stomach, drug is only effective within 30 - 90 mins after oral administration
Dose: available as 10 mg tabs
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