Ibuprofen
Ibuprofen/ Advil, Brufen, Nurofen, Panafen Plus
Classification: NSAID
Action: : anti-inflammatory, analgesic, antipyretic, related to inhibition of prostaglandin synthesis. NSAIDs block 2 enzymes, Cox 1 and Cox2. Cox1 is present in all tissues, involved in many body functions, including blood clotting, protecting the stomach lining and maintaining sodium and water balance in the kidney. Cox 2 is active at sites of trauma or injury when more prostaglandins are needed. THERefore it blocks inflammation and also blocks protection of the stomach lining as well as blocking the kidneys regulation of water.
Adverse reaction: : nausea, dyspepsia, gI pain, constipation, diarrhoea or flatulence. potential for gi bleeding with chronic use. headache, dizziness, somnolence and fatigue. Platelet and bone marrow depression with chronic use. Rash and mouth sores may develop , anaphylactic shock in cases of hypersensitivity.
Dose: mild to moderate pain 1.2 g to 1.6 g PO tid or qid,
Contraindications
hypersensitivity, syndrome of nasal polyps, bronchospastic reaction to aspirin or other NSAIDS
Drug-drug
antihypertensives, furosemide, thiazide diuretics. aspirin, oral anti-coags
less important: corticosteroids, cyclosporin, digoxin, lithium, methotrexate.
alcohol, sun exposure.
Care considerations found in many combo products,
Use cautiously in individuals with GI disorders, peptic ulcer, hepatic or renal disease,
cardiac decompensation, hypertension or known coag defects.
Not recommended during pregnancy.
Check renal and hepatic function.
Can prolong INR and bleeding time, alters urea, serum creatinine, potassium levels and others.
Teaching
Take with food to minimise GI reactions.
Therapeutic effects for arthritis take 2 to 4 weeks.
Conncomittant use with aspirin, alcohol or corticosteroids may increase risk of GI adverse reactions.
Classification: NSAID
Action: : anti-inflammatory, analgesic, antipyretic, related to inhibition of prostaglandin synthesis. NSAIDs block 2 enzymes, Cox 1 and Cox2. Cox1 is present in all tissues, involved in many body functions, including blood clotting, protecting the stomach lining and maintaining sodium and water balance in the kidney. Cox 2 is active at sites of trauma or injury when more prostaglandins are needed. THERefore it blocks inflammation and also blocks protection of the stomach lining as well as blocking the kidneys regulation of water.
Adverse reaction: : nausea, dyspepsia, gI pain, constipation, diarrhoea or flatulence. potential for gi bleeding with chronic use. headache, dizziness, somnolence and fatigue. Platelet and bone marrow depression with chronic use. Rash and mouth sores may develop , anaphylactic shock in cases of hypersensitivity.
Dose: mild to moderate pain 1.2 g to 1.6 g PO tid or qid,
Contraindications
hypersensitivity, syndrome of nasal polyps, bronchospastic reaction to aspirin or other NSAIDS
Drug-drug
antihypertensives, furosemide, thiazide diuretics. aspirin, oral anti-coags
less important: corticosteroids, cyclosporin, digoxin, lithium, methotrexate.
alcohol, sun exposure.
Care considerations found in many combo products,
can be extremely toxic, esp to liver
(children die from overdose by combo meds)
cardiac decompensation, hypertension or known coag defects.
Not recommended during pregnancy.
Check renal and hepatic function.
Can prolong INR and bleeding time, alters urea, serum creatinine, potassium levels and others.
Teaching
Take with food to minimise GI reactions.
Therapeutic effects for arthritis take 2 to 4 weeks.
Conncomittant use with aspirin, alcohol or corticosteroids may increase risk of GI adverse reactions.
Comments
Post a Comment