Fentanyl

Fentanyl S8

fentanyl citrate 
Actiq, Fentanyl injection, Sublimaze

Classification: narcotic and opioid analgesics S8

Action: Unknown. Binds with opiate receptors in CNS, altering both perception of and
 emotional response to pain.

Adverse/Side Effects:
     CNS: sedation, somnolence, clouded sensorium, euphoria, dizziness, headache, confusion,
 asthenia, nervousness, hallucinations, anxiety, depression, siezures
     CV: hypotension, hypertension, arrhythmias, chest pain.
     GI: nausea, vomiting, constipation, ileus, abdominal pain, dry mouth, naorexia,
          diarrhoea, dyspepsia
      GU: urinary retention
     Respiratory: respiratory depression, hypoventilation, dyspnoea, apnoea
     Skin: reaction at application site (erythema, papules, oedema), pruritus
     Other: physical dependence.

Drug to drug: CNS depresants, general anaesthetics, hypnotics, MAO i's , sedatives, tricyclic antidepressants.
AVOID ALCOHOL

USE CAUTION IN COPD, hepatic or renal disease, elderly or debilitated.

Dose:
      Available Forms
           Injection
           Lozenge
           Transdermal system:
       Adults: 50 to 100 mcg IV q 2 to 3 minutes until desired effect.
                  25 to 50 mcg IV or IM (Elderly to high risk patients)
        Children: 2 to 12 yrs: 2 to 3 mcg/kg IV
     
        For Chronic Pain: 1 transdermal patch 25 mcg/hours. Wear for 72 hours.
                                    May be adjusted to q 6 days.
                                   Lozenge initial dose 200 mcg, repeat in 30 minutes if required

Comments

Post a Comment

Popular posts from this blog

Clopidrogel

Clopidrogel hydrogen sulfate/ Iscover Plax Plavix                                 preg risk B Indications: to reduce atherosclerotic events where there is MI, CVA or peripheral arterial disease.   Action: ANTIPLATELET inhibits platelet aggregation, by inhibition of binding of ADP to its platelet receptor.Irreversible modification of platelet, LASTS FOR LIFETIME OF PLATELET-lasts 5days, indicated for those intolerant to aspirin. Adverse : CNS: headache, dizziness, fatigue, depression, pain ENT: rhinitis, epistaxis GI: haemorrhage, abdo pain, dyspepsia, gastritis, constipation, diarrhea, ulcers GU: UTI Haematologic: purpura Musculoskeletal: arthralgia Respiratory: bronchitis, coughing, dyspnea, upper respiratory tract infection Skin : rash, pruritus Flu-like syndrome Contraindications ...
Read more

Insulin

Insulin Classifications : exogenous Insulin Action: Is a hormone that promotes the storage of the body’s fuels 1.     Simulates the synthesis of glycogen from glucose (   glyconeogenesis ) 2.     Reacts with specific receptor sites to allow glucose into the cell –      Replaces endogenous insulin - Suppresses lipolysis – Glyco -neo-genesis:   The formation of glycogen from noncarbohydrates, such as protein or fat, by conversion of the latter to d-glucose.(medi lexicon) – Conversion of lipids into fat Various insulins available are processed within the body like endogenous insulin – Peak, onset and duration vary based on preparation Indications – Treatment of type 1 diabetes mellitus (IDDM) – Treatment of type 2 diabetes mellitus in people whose diabetes cannot be controlled by diet or other agents - treatment of type 2 diabetics who are stressed - managment of DKA, hyperkalaemia, and marked...
Read more

Glibenclamide

Glibenclamide (Sufonylurea) Classifications : Sufonylurea- works only if pancreas has functioning beta cells. Adjunct to diet and exercise to lower blood glucose levels in type 2 DM Action:  Stimulate insulin release from the beta cells in the pancreas – They improve binding to insulin receptors -           Metabolized in liver and excreted in bile and urine Safer for those with renal disease. Adverse reactions : –Hypoglycaemia –GI distress : anorexia, nausea, vomiting, heartburn, diarrhoea –Allergic skin reactions   Contraindications : hypersensitivity, dka, diabetes complicated by fever, trauma, surgery ,renal or hepatic disease etc. Not for type 1 diabetics. Not for pregnancy. Care considerations : Learn to recognize signs of hypoglycaemia and hyperglycaemia to effectively manage condition. Drug-drug : – Drugs that acidifies the urine –Beta blockers –Alcohol 
Read more