Naloxone

Naloxone hydrochloride/ Narcan

Classification: antagonist, antidote

Action: Thought to displace previously administered narcotic analgesics from their receptors.
             Competitive antagonism. Reverses Buprenorphine, Pethidine, Morphine

Adverse/Side Effects
              CNS: seizures, tremors
              CV: tachycardia, hypertension (if dose high), hypotension, ventricular fibrillation.
              GI: nausea, vomiting (if dose high).
              Respiratory: pulmonary oedema
              Skin: sweating
              Other: withdrawal symptoms (in narcotic - dependents)

Available forms: Injection


Dose: 0.4 to 2 mg IV, SC or IM, repeated q 2 to 3 minutes, prn.
            If no response after 10mg administered, query toxicity due to narcotic.

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